Despite prior work examining the nuclear lamina in G4C2 and DPR overexpression based model systems [18, 37], which concluded that there were nuclear membrane alterations in those models, our current analyses using a large number of iPSC lines and postmortem patient tissues suggest that there are in fact no overt alterations to overall nuclear morphology or the frequency of Lamin B1 invaginations in C9orf72 ALS/FTD. This evidence concerns the gene LMNB1 and frontotemporal dementia.