Plasma concentrations of SYN-1 were more than double in septic shock patients on day 1 (185 [90–381] ng/mL) compared to healthy volunteers (p < 0.001), whereas the opposite was true for S1P (p < 0.001), with septic shock patients reporting values 3.5 times lower (86.5 [63.7–120.0] ng/mL). This evidence concerns the gene SYN1 and septic shock.