SEMA4D (CD100) binds 3 types of receptors, Plexin-B1 (PLXNB1), Plexin-B2 (PLXNB2), and CD72, which are all expressed by APCs (B cells, monocytes, DCs), endothelial cells, and tumor cells [122]. Here, PLXNB2 is linked to neoplasm.