The results showed that cell proliferation, colony formation and tumor sphere formation were inhibited by TRAF3IP2-AS1 overexpression compared with the negative control in UOK109 cells, and knockdown of TRAF3IP2-AS1 significantly increased cell proliferation, colony formation and tumor sphere formation in 786-O cell line (Fig. 2d–f). Here, TRAF3IP2 is linked to neoplasm.