Xp11.2 translocation renal cell carcinoma (Xp11.2 tRCC), also known as transcription factor binding to IGHM enhancer 3 (TFE3)-fusion associated RCC, is recently stratified in the MiT (microphthalmia transcription factor) family tRCC as a new subset of RCC in the 2016 WHO classification [1]. This evidence concerns the gene TFE3 and renal cell carcinoma.