PTEN and neoplasm: As a tumor suppressor gene,upregulation of TRAF3IP2-AS1 markedly inhibited PARP1 expression by binding to its mRNA directly to stimulate m6A methylation which led to mRNA decay of PARP1 and enhanced the expression of PTEN through absorbing miR-200a-3p, miR-153-3p and miR-141-3p.