Interestingly, α1 integrinI (ITGA1) mRNA and adenylyl cyclase 9 (ADCY9) mRNA competed for binding to miR-181b, and ZEB1 upregulated ITGA1 to activate a miR-181b-regulated ceRNA network that increased metastasis of lung adenocarcinomas [43]. Here, ZEB1 is linked to lung adenocarcinoma.