Therefore, our results indicate that TRAF3IP2-AS1 plays a critical role in tumor progression as a tumor suppressor in NONO-TFE3 tRCC, which highlights a novel regulatory mechanism underlying tumorigenesis and tumor development. The gene discussed is TRAF3IP2; the disease is renal cell carcinoma associated with Xp11.2 translocations/TFE3 gene fusions.