Last, we demonstrated that TRAF3IP2-AS1 acts as a tumor suppressor during tumor progression and upregulation of TRAF3IP2-AS1 can inhibit cell proliferation, migration and invasion in NONO-TFE3 tRCC (Fig. 9). Here, TRAF3IP2 is linked to renal cell carcinoma associated with Xp11.2 translocations/TFE3 gene fusions.