Since key genes involved in Wnt/ β-catenin signaling such as Wnt1, LRP6, β-catenin, TCF/LEF and CD44 as well as in Notch signaling pathway such as Notch1, Notch2, JAG1 and DLL1 were known as direct target genes of miR-34a-5p [15] and regarding to the important roles of these signaling pathways in cancer stemness maintenance, miR-34a-5p could be a pivotal molecule in suppression of CSCs. This evidence concerns the gene HNF4A and cancer.