Similarly, an ongoing phase I/II study (NCT03164772) is evaluating the efficacy and safety of mRNA Vaccine (BI 1361849) in the combination of checkpoint inhibitors, anti-PD-L1 (durvalumab), and anti-CTLA-4 (tremelimumab) for the treatment of NSCLC. This evidence concerns the gene CD274 and non-small cell lung carcinoma.