Fortunately, a recent research base on single-cell multiomics sequencing reported that somatic copy number alterations are prevalent in fibroblasts, especially in CAFs, and five genes (BGN, RCN3, TAGLN, MYL9, and TPM2) are identified as fibroblast-specific biomarkers of poorer prognosis of colorectal cancer [38]. This evidence concerns the gene RCN3 and colorectal cancer.