The most common autosomal recessive form is p47phox deficiency that accounts for 25% of CGD cases in Western countries with a higher frequency in Eastern countries where the number of consanguineous marriages is elevated.3,4 Although generally less severe than the X-linked form, p47phox-deficient CGD (p47phoxCGD) still causes significant morbidity and mortality mainly due to severe gastrointestinal disorders.5 For years, hematopoietic stem cell transplantation6 has been the only cure for individuals affected by CGD but the advent of ex vivo gene therapy has unveiled new therapeutic options.7 Here, NCF1 is linked to chronic granulomatous disease.