In preclinical models of active tuberculosis in the mouse and rabbit, treatment with CC-11050 plus isoniazid reduced the number and size of lung lesions, ameliorated lung pathology, and reduced lung M tuberculosis colony-forming unit counts to a greater extent than did isoniazid alone.5, 6 In M tuberculosis-infected rabbits, CC-11050 additionally reduced the expression of multiple matrix metalloproteinase genes (particularly MMP12) and reduced the extracellular deposition of collagen in the lung.6 The gene discussed is MMP12; the disease is tuberculosis.