Whilst RGM-mediated signaling is specific to NEO1, NET1 can signal via both NEO1 and deleted in colorectal cancer (DCC), a structural homologue of NEO1 (Huyghe et al., 2020; Keino-Masu et al., 1996; Wilson and Key, 2006; Xu et al., 2014). Here, NEO1 is linked to colorectal cancer.