In contrast, HDL2-C and apoA-I levels in CAD patients with obesity were lower than those of the normal BMI group (0.55 ± 0.13 mmol/L vs 0.67 ± 0.11 mmol/L, 0.98 ± 0.12 g/L vs 1.12 ± 0.13 g/L, respectively), while MCP-1 levels in CAD patients with obesity were the highest among the three groups (normal 53.02 ± 10.76 mmol/L, overweight 56.21 ± 13.12 mmol/L, obesity 62.83 ± 15.63 mmol/L). This evidence concerns the gene APOA1 and obesity due to melanocortin 4 receptor deficiency.