To test whether mutation-dependent DNA methylation differences were restricted to 1p/19q non-codeleted gliomas (astrocytomas), we analysed the genome-wide methylation profiles of (i) IDH1/2 mutated, 1p/19q codeleted gliomas (oligodendrogliomas, TCGA), (ii) acute myeloid leukemias (TCGA) and (iii) chondrosarcomas. Here, IDH1 is linked to central nervous system cancer.