LEP and polycystic ovary syndrome: Recently, there has been an increasing interest in exploring the changes in circulating adipokines in PCOS patients; meta-analysis of changes in many important adipokines in context of PCOS such as omentin-1 [18], leptin [19, 20], interleukin-6(IL-6) [21], visfatin [22], tumor necrosis factor-alpha (TNF-a) [23], adiponectin [24], and retinol-binding protein 4 (RBP4) [25] has been performed previously.