Indeed sequence data derived from patients with biliary atresia and other cholangiopathies should be reexamined focusing on mutations in the last exon of human NCKAP1L after the conventional stop codon, as our data potentially suggest that the genomic region currently recognized as the 3’ UTR could encode a previously unannotated minor protein isoform. The gene discussed is NCKAP1L; the disease is biliary atresia.