APOE and coronary artery disorder: Our results showed that most genes were enriched in regulation of leukocytic activation, such as tumor necrosis factor superfamily member 9 (TNFSF9), which is up-regulated in CD14+ monocytes from CAD patients and may promote differentiation of monocyte-derived dendritic cells [25], mitogen-activated protein kinase kinase kinases 8 (MAP3K8), which is up-regulated in CD14+ monocytes from CAD patients and involved in the enhancement of C–C chemokine receptor type 2 (CCR2) expression and abilities of migration and adhesion on Ly6ChighCD11clow monocytes of ApoE−/− mice fed a high-fat diet [26].