PFKFB3 and coronary artery disorder: In sequencing data, the genes FOSL2, HBB, OSM, PFKFB3, and PDK4 were up-regulated and the genes RHOB, PTGER4, CCL3L, DENND2D, and ACCS were down-regulated in CD14+ monocytes from CAD patients compared with controls (Figure 4A).