These DEGs enriched in cell adhesion molecules include up-regulated genes, like cell adhesion molecule 3 (CADM3), E-selectin (SELE), and Claudin 5 (CLDN5), and down-regulated genes, such as neuronal guidance protein neogenin 1 (NEO1), which is suppressing in CD14+ monocytes from CAD patients and its limited expression could induce the polarization of monocytes [43]. The gene discussed is CLDN5; the disease is coronary artery disorder.