LINC00632 and lung adenocarcinoma: In addition, hsa_circ_0096157 enhances cisplatin resistance via regulating the p21/CCND1/CDK4/BCL2 apoptosis signaling pathway65, and CDR1as has been identified to contribute to both cisplatin and pemetrexed chemoresistance in lung adenocarcinoma via the EGFR/PI3K signaling pathway66.