Hsa_circ_0035483 contributes to gemcitabine-induced autophagy and facilitates resistance of renal cell carcinoma (RCC) to gemcitabine via the miR-335/Cyclin B1 axis80; similarly, circEIF6 facilitates cisplatin resistance via miR-144-3p/TGF-α in thyroid carcinoma81. This evidence concerns the gene TGFA and renal cell carcinoma.