Interestingly, surviving α‐MNs harboring larger FUS aggregates in FUS‐ALS lumbar spinal cord (Fig 5I, yellow arrows) displayed markedly reduced DYRK3 immunoreactivity both in the cytoplasm (Fig 5I, red arrowheads and Fig 5J), as well as in the nucleus (Fig 5I, red arrowheads and Fig 5J). Here, DYRK3 is linked to amyotrophic lateral sclerosis.