The findings that, after dissipation of the stress, ALS patient fibroblasts show a defective induction of DYRK3 expression, together with the reduced expression levels of DYRK3 observed in α‐MNs in the lumbar spinal cord of ALS patients bearing the R521C mutation suggest that the deregulated functions of Hsp90 and DYRK3 may contribute to the altered cell stress response and the accumulation of SGs observed in ALS. The gene discussed is HSP90AB1; the disease is amyotrophic lateral sclerosis.