In addition, only ALL treatment significantly reduced (by 20%, P = 0.0177) the frequency of CD68-positive activated microglia (Fig. 2G and I) while other treatments did not have a significant impact (P = 0.1353 for Npc1−/− ADLL, P = 0.0553 for Npc1−/− ADL compared to Npc1−/− UT). Here, NPC1 is linked to acute lymphoblastic leukemia.