PDHX and acute lymphoblastic leukemia: E1 alpha subunit protein levels in PDHC were significantly increased by ADLL (29.1%, P = 0.0146), ALL (43.3%, P = 0.0004) and ADL (34.17%, P = 0.0044) in the cerebellum from treated Npc1−/− mice (Fig. 6D and E), with no changes in El beta, E2 or E3bp.