NPC1 and acute lymphoblastic leukemia: Quantification of the major GSL species confirmed that levels of GM2Gc (the most abundant GSL in the mouse liver) were decreased significantly with all AL analogues tested (26.7% ADLL: P = 0.0002, 45% ALL: P < 0.0001, 29% ADL: P < 0.0001), while GM3Gc levels were only reduced significantly by ALL (54.8%: P = 0.0314) relative to untreated Npc1−/− mice (Fig. 3A).