NPC1 and acute lymphoblastic leukemia: CHO cells treated with 1 mM ALs for 24 h resulted in normalization of MitoSOX staining with all three drugs (P < 0.0001, compared to NPC1 UT) (Fig. 3E and Supplementary Fig. 3), and a significant decrease in MitoTracker Green (ADLL 16.8% P = 0.0150; ALL 17.1% P = 0.0133; ADL 15.8% P = 0.0215) (Fig. 3E and Supplementary Fig. 3).