PCSK9 and familial hyperaldosteronism: The reduced heterogeneity might also indicate the heterogeneous nature of FH population, as reported in previous studies that the predictive value of some traditional risk factors for future MACEs was different from the general population (53, 54) Of note, although PCSK9 showed the prognostic value in FH patients, further steps are still needed to confirm it in large cohorts and different ethnic population.