Baseline PCSK9 could not significantly predict stroke when combining risk estimate by random effect models both for per 1-SD increase (RR, 1.022; 95% CI: 0.771–1.354; I2 = 57.6%, Pheterogeneity = 0.095) and for the highest tertile vs. the lowest tertile (RR, 1.051; 95% CI: 0.567–1.918; I2 = 63.1%, Pheterogeneity < 0.001). This evidence concerns the gene PCSK9 and Stroke.