TTP is mainly characterized by neurological involvement, while only a limited proportion of patients (25%) show renal involvement; TTP patients usually exhibit congenital or acquired ADAMTS 13 deficiency leading to the accumulation of the ultra-large multimers of von Willebrand factors (vWFs) that cause platelet aggregation and consequently microvascular thrombosis (86). Here, VWF is linked to thrombotic thrombocytopenic purpura.