While gene expression of major key players in NSCLC, such as Keap1, Stk11/Lkb1, Kras, cJun, cMyc, Notch1, Notch3, or Nkx2-1, was not altered, KPCRISPR showed an increase in the expression of genes involved in Wnt signaling, while KPGEMM upregulated the Egfr signaling pathway (Supplementary Figures 3F,G). This evidence concerns the gene NOTCH3 and non-small cell lung carcinoma.