Analysis of lung lineage-specific marker expression, such as the adenocarcinoma marker thyroid transcription factor-1 (TTF1), the tracheal club cell marker Scgb1a1 (CC10), or the alveolar type II specific surfactant protein C (SftpC), an additional marker for adenocarcinomas, showed similar expression patterns between KPGEMM and KPCRISPR (Figure 1I). This evidence concerns the gene NKX2-1 and adenocarcinoma.