NOTCH1 and non-small cell lung carcinoma: While gene expression of major key players in NSCLC, such as Keap1, Stk11/Lkb1, Kras, cJun, cMyc, Notch1, Notch3, or Nkx2-1, was not altered, KPCRISPR showed an increase in the expression of genes involved in Wnt signaling, while KPGEMM upregulated the Egfr signaling pathway (Supplementary Figures 3F,G).