KEAP1 and AIDS dementia complex: Among the most commonly mutated are E3 ligases, such as APC or KEAP1, key enzymes of the ubiquitin system, as well negative regulators of (stem) cell growth and transformation, such as STK11/LKB1 and PTEN (altered in 403/503 ADC (80%) and 437/477 SCC (94 (Figure 4A and Supplementary Figure 4A).