NFE2L2 and neoplasm: Loss of Stk11/Lkbn1 impacts tumor cell metabolism and increases ROS production, while elevated abundance of Nrf2 establishes ROS homeostasis, enabling tumor cells to grow under stress conditions (Ma, 2013; Faubert et al., 2014; Kaufman et al., 2014; Galan-Cobo et al., 2019).