In fact, it has been proved by previous studies that immature macrophages from patients with IBD mainly produce IL-1β to induce Th17 cells and pathological IFN-γ+ IL-17+ T cells, which come from autologous colon CD4+ T cells (Ramesh et al., 2014; Chapuy et al., 2019; Chapuy et al., 2020). This evidence concerns the gene IL1B and inflammatory bowel disease.