Therefore, tumor-derived exosomes may contribute to DTC awakening by altering the ECM components and provoking abnormal deposition of molecules like fibronectin (Mu et al., 2013; Costa-Silva et al., 2015; Sung et al., 2015), collagen, laminin (Mu et al., 2013), annexins, and integrins (Hoshino et al., 2015; Keerthikumar et al., 2015). This evidence concerns the gene FN1 and neoplasm.