CDH1 and neoplasm: Tumor-derived EVs, carry proteins like Tspan8 (Nazarenko et al., 2010), soluble E-cadherin (Tang et al., 2018), or Angiopoietin II (Xie et al., 2020) that are directly involved in the activation of the endothelium, or indirectly through the induction of pro-vasculogenic phenotypes in stromal cells (e.g., fibroblasts) (Cho et al., 2012; Chowdhury et al., 2015) or pro-angiogenic immune cells (Peinado et al., 2012).