CCL2 and lung cancer: It was recently shown that neuroblastoma-derived EVs (Nakata et al., 2017) and lung cancer-derived EVs (Li et al., 2016) are captured by bone marrow-derived MSCs in vitro, inducing the secretion of pro-tumoral cytokines and chemokines like interleukin-6 (IL-6), IL-8/CXCL8, vascular endothelial cell growth factor (VEGF) and monocyte-chemotactic protein-1 (MCP-1) (Li et al., 2016; Nakata et al., 2017).