Due to the strong connection between awakening and PMN formation, these combined studies could also include certain exosomal markers of PMN, some of which have already been correlated with poor prognosis, such as c-MET in the case of lung metastasis in melanoma patients (Peinado et al., 2012) or MIF in the case of liver metastasis of pancreatic cancer (Costa-Silva et al., 2015). This evidence concerns the gene MET and melanoma.