MEP1B and cancer: Furthermore, the isoform meprin β′ mRNA, containing an additional 5′ sequence, was discovered in human colon adenocarcinoma cell line (HT29-18C1) (Dietrich et al., 1996), human breast cancer cell lines (MCF-7 and SK-BR-3), human osteosarcoma cell line (U-2 OS), and the human pancreatic cancer cell line (BxPC-3), indicating its aspect in cancer (Matters and Bond, 1999).