Similarly, NPs made of lipid–poly(hypoxic radiosensitized polyprodrug), IO conjugated with epidermal growth factor receptor (EGFR), and RE have also been reported to enhance the sensitivity of radiotherapy in glioma cells by increasing the oxidative stress (Bouras et al., 2015; Hua et al., 2018; Lu et al., 2019). The gene discussed is EGFR; the disease is central nervous system cancer.