Consistent with these results, C1 also exhibited an increase in chemokines, interleukins, interferons, and other important cytokines and their receptors, such as CCL5 (recruiting MDSC to migrate to tumor areas), IL-10 (a cytokine synthesis inhibitor), and TGF-β3 (having a wide range of immunosuppressive activities) (40–42) (Figure 4F and Figures S6A, B). Here, IL10 is linked to neoplasm.