The results showed that the two subtypes had frequent CNVs in the regions where oncogenes and tumor suppressor genes (e.g. MYC and TP63), as well as cell cycle regulators (e.g. CDK3, CDK8, and MAPK11) were located, which indicated the CNVs might have a profound impact on the tumorigenesis and progression of HCC. Here, MAPK11 is linked to hepatocellular carcinoma.