Moreover, NEAT1 could contribute to cell proliferation, apoptosis, and invasion in lung cancer via the miR-1224/Kruppel like factor 3 (KLF3) axis, and promoted autophagy by regulating miR-204/autophagy related 3 (ATG3) and enhanced cell resistance to sorafenib in hepatocellular carcinoma (10, 11). This evidence concerns the gene ATG3 and hepatocellular carcinoma.