The multivariate analysis of Linc00665 and pCR adjusted by HR status, HER2 status, Ki67 level, tumor size, lymph node status and menopausal status suggested that Linc00665 expression was an independent predictor for pCR (OR = 0.351, P = 0.040, 95% CI: 0.125–0.936). The gene discussed is MKI67; the disease is neoplasm.