Then, the multivariate Cox analysis was performed and the result indicated that higher age, the race of black, larger tumor size, higher grade, histological type of mucinous adenocarcinoma and signet ring cell carcinoma, higher AJCC N status, RCC, lung metastasis, bone metastasis, without surgery, without chemotherapy, and elevated CEA were independently associated with poor OS of CCLM patients (Table 2). The gene discussed is CEACAM5; the disease is bone metastasis.