The dependence of various cancers on RAS/RAF/MAPK pathway to rewire their glucose metabolism and the importance of mitochondrial PDK1 as a central regulatory switch at the crossroads of glycolysis to oxidative phosphorylation (OXPHOS) (47, 54), besides higher glucose fermentation rate/s shown by BRAFV600E cells prompted us to investigate if PDK1 had any role in such metabolic reprograming and cancer progression. This evidence concerns the gene PDK1 and cancer.