Recently, though a Wnt inhibitor (ICG-001) was reported to inhibit DRP1 activity in a panel of colorectal cancer cell lines, and induce an early ER (endoplasmic reticulum) stress by activating ATF4, DDIT3, TRIB3 and ASNS, however clues about how oncogenic transformation implicates mitochondrial physiology and associated tumorigenesis of these cells are lacking (17). The gene discussed is DNM1L; the disease is colorectal cancer.