MFN1 and colorectal carcinoma: It was found that BRAFV600E cells had higher levels of pro-fission mediator DRP1 as well as its activated form pDRP1S616 compared to BRAFWT cells; however, the fusion mediating protein expression (Mfn1/2) did not vary significantly (Figure 1B), indicating the more prominent role of pro-fission GTPase DRP1 in BRAF driven CRC tumors.