A significant reduction in N-cadherin as well as vimentin with a concomitant up-regulation in E-cadherin was observed upon DRP1/PDK1 silencing or 2-DG treatment (Figure 4F), which indicates a possible role of mitochondrial fission and glycolytic metabolism in inducing EMT in BRAFV600E metastatic CRC (m-CRC). This evidence concerns the gene CDH2 and colorectal carcinoma.