Further studies showed similar effects produced by ASOs with other types of chemical modification10 and small interfering RNA (siRNA) duplexes targeting expanded CAG repeats in HD, SCA3, and DRPLA cell lines.11, 12, 13, 14, 15 Moreover, recent studies have shown that chemically modified ASOs and single-stranded siRNAs targeting CAG repeats suppress mutant proteins in the CNS of HD,16,17 SCA1, and SCA318 mouse models. This evidence concerns the gene ATXN3 and Huntington disease.