The remaining mice in the castrated cohort showed signs of high-grade prostatic intraepithelial neoplasia with or without focal carcinomatous transformation characterized by CK8 positive atypical cells that formed distorted/ill-defined glands within the stroma (HGPIN/ADENO, Figures 6B,C; found in 3 out of 19, corresponding to 16% of mice; Figure 6A); or signs of glandular involution/tumor regression (REG, Figures 6B,C; found in 5 out of 19, corresponding to 26% of mice Figure 6A). This evidence concerns the gene KRT8 and neoplasm.