Studies in mouse or rat models have used higher concentrations of levetiracetam up to 600 mg/Kg day without showing any additional side effect (34, 35), therefore suggesting the possibility of testing high-doses of levetiracetam in vivo in prostate cancer models, with the aim to target both MCs and those scattered adenocarcinoma cells expressing mild levels of SV2A. This evidence concerns the gene SV2A and Familial prostate cancer.