The occurrence of virulence factors in enterococci other than E. faecium and E. faecalis is either rare or does not occur (Beukers et al., 2017), thus identification of the ATP-dependent Clp protease proteolytic subunit (ClpP); responsible for the adaptation to multiple stressors via degradation of misfolded and accumulating proteins (Michel et al., 2006), and the fibrinogen binding MSCRAMM (Fss3); responsible for binding to host fibrinogen and collagen to initiate infection (Sillanpää et al., 2009), was unexpected. Here, CLPP is linked to infection.