POMC and neoplasm: No obvious interclass differences were found in gender, age, first operation, disease duration, BMI, 24-h preoperative UFC (P24h-UFC),combined LDDST and HDDST (combined LH), preoperative morning serum cortisol (PMS-C), preoperative ACTH, tumour size (microadenoma or macroadenoma) or cavernous sinus invasion evaluated on MRI (IOMRI).