A Renal Insufficiency Cohort (CRIC) identifies enhanced DNA methylation in genes of IQ motif and Sec7 domain 1 (IQSEC1), nephronophthisis 4 (NPHP4), and transcription factor 3 (TCF3) in participants with stable renal function while compared to those with rapid loss of eGFR (Wing et al., 2014). The gene discussed is IQSEC1; the disease is Renal insufficiency.