PLAT and Stroke: Neuroserpin, a tissue plasminogen activator (tPA) inhibitor, has been reported to exert neuroprotective effects in cerebral ischemic and hemorrhagic stroke mouse model (Yepes et al., 2000; Cinelli et al., 2001; Zhang et al., 2002; Lebeurrier et al., 2005; Wu et al., 2010; Rodriguez Gonzalez et al., 2011b; Gelderblom et al., 2013; Li et al., 2017) and stroke patients (Rodriguez Gonzalez et al., 2011c; Wu et al., 2017).