APP and Alzheimer disease: There is accumulating evidence showing that hyperglycemia conditions like diabetes possess a greater risk of impairment to the neuronal system (González-Reyes et al., 2016; Pruzin et al., 2018; Rojas-carranza et al., 2018) because high glucose levels exacerbate oxidative stress, accumulation of amyloid-beta peptides, and mitochondrial dysfunction, and impair cognitive functions, and cause neurodegeneration conditions like Alzheimer’s diseases (Macauley et al., 2015; Gaspar et al., 2016; Kim et al., 2016; Rom et al., 2018; Silzer and Phillips, 2018).