Aqueous extract exhibits anti-allergic actions through inhibition of local immunoglobulin E, histamine release and TNF-α production in 48/80 induced systemic anaphylaxis in rats. Dose: 0.001–1 g/kgShin et al. (2001). Polyphenolic rich extract of Magnolia officinalis suppressed the production of inflammatory mediators, NO, pro-inflammatory cytokines, TNF-α and IL-6, and inhibition of TLR3 and NF-κB activation. Dose: 10 and 200 mg/kgFang et al. (2015). This evidence concerns the gene TLR3 and anaphylaxis.