Alcoholic extract of leaves decreased histamine and GM-CSF produced by an IgE-mediated hypersensitive reaction, and inhibited eotaxin and IL-8 secretion in a TNF-α and IL-4-induced allergic reaction. Dose: 10 mg/mlWirotesangthong et al. (2008). The gene discussed is IGHE; the disease is hypersensitivity reaction disease.