Microglial nodules and elevated immunostaining for microglial reactivity markers (e.g., IBA1, HLA-DR, and CD68) were detected in numerous brain autopsies of COVID-19 patients also showing recent and older hypoxic/ischemic injuries (Al-Dalahmah et al., 2020; Kantonen et al., 2020; Matschke et al., 2020), accompanied by marked neuronal loss among the cerebral cortex, hippocampus, medulla, and cerebellar Purkinje cell layer (Al-Dalahmah et al., 2020; Solomon et al., 2020). The gene discussed is AIF1; the disease is COVID-19.