TREM2 and neurodegenerative disease: Accordingly, in a patient with increased CSF and serum levels of IL6, IL8, and TNF, the microglial marker triggering receptor expressed on myeloid cells 2 (TREM2), associated with neurodegenerative diseases and phagocytosis, was also increased in the CSF, indicating an active inflammatory process in the spinal cord meningeal space (Pilotto et al., 2020a,b).