Microglial PRR signaling is fundamental to the antiviral IFN response in the brain, particularly at early time points after infection (see section “Putative Responses of Microglia to SARS-CoV-2 CNS Infection”) (Nakagaki et al., 2005; Wheeler et al., 2018; Mangale et al., 2020). This evidence concerns the gene IFNA1 and infection.