In the periphery, there are several inflammatory changes associated with COVID-19, one being the activation of the NLR family pyrin domain containing 3 (NLRP3) inflammasome (Freeman and Swartz, 2020; van den Berg and te Velde, 2020), which potentially contributes to generating the previously discussed cytokine storm (Mehta et al., 2020). The gene discussed is NLRP3; the disease is COVID-19.