Interestingly, expressing a mutant VPS35 associated with Alzheimer’s disease (L625P) rescues the effect of VPS35 knockdown on LTP, whereas expression of the PD-associated mutant (D620N) does not (Temkin et al., 2017), demonstrating that the PD-associated mutant contributes to defects in LTP. This evidence concerns the gene VPS35 and early-onset autosomal dominant Alzheimer disease.