The results indicated that Atp6v1f, Arpc5, Adcyap1r1, Ndufb6, and Psmc6 were distinctly dysregulated in the hypothalamus of the depression-susceptible group, while Gys1, Pgp, Klc1, Chka, Ncstn, Ndufa6, and Kyat1 were distinctly dysregulated in the anxiety-susceptible group. Here, KYAT1 is linked to major depressive disorder.