On the other hand, three different α-HA of amino acid origin (α-Hydroxyisovaleric acid, α-Hydroxybutyric, and 2,3-Dihydroxybutanoic acid) were significantly increased in samples from mild and severe COVID-19 patients and positively correlated with CRP and LDH and negatively with SO2 and serum albumin. This evidence concerns the gene CRP and COVID-19.