Shimizu, et al. reported that nasal secretions from chronic rhinosinusitis contain higher amounts of HMGB1, and TNF-α stimulated the production and secretion of HMGB1, and HMGB1 stimulated the production and secretion of IL-6 and IL-8 by cultured nasal epithelial cells. This evidence concerns the gene HMGB1 and chronic rhinosinusitis.