To explore whether the inhibition of PTE on the proliferation of glioma cells is related to the induction of apoptosis, T98G, LN18, U87 and LN229 cells were treated with different concentrations of PTE for 48 h and flow cytometry with FITC Annexin V/PI stain was used to detect apoptosis. The gene discussed is ANXA5; the disease is glioma.