In addition, in order to further explore the correlation between ERK1/2 and JNK with PTE-induced glioma cell apoptosis, we pretreated with the specific MEK inhibitor U0126 and JNK inhibitor SP600125; the MTT and western blotting results showed that specific JNK and MEK inhibitors reversed the inhibition of PTE on glioma cell proliferation and PTE-induced glioma apoptosis. The gene discussed is MAPK8; the disease is central nervous system cancer.