At 4 weeks after PHMG exposure, there were some upregulated genes that have been implicated in mediating pulmonary disorders, such as ALOX15, which induces acute lung injury8, and PDE1A, CHI3L1, and BPIFB1, which play a critical role in pulmonary fibrosis9–11. The gene discussed is BPIFB1; the disease is lung disorder.