TREM2 and frontotemporal dementia: Less frequently, mutations in the genes encoding TAR DNA-binding protein 43 (TDP-43), valosin containing protein (VCP), and the charged multivesicular body protein 2B (CHMP2B), Ubiquilin 2 (UBQLN2), prion protein (PRNP) and Triggering Receptor Expressed on Myeloid Cells 2 (TREM2) have been reported3–6 and 16 pathogenic mutations in these genes have been detected in Italian FTD patients and explain part of the disease heritability (Table S1, Fig. 1).