Moreover, we report one SORL1 mutation in the valosin-containing protein (VCP) domain (p.R744X) that was associated to AD with severe language impairment and PPA and was not detected in a member of the same family that had been initially diagnosed with AD and successively with FTD with memory onset (Table 3, Fig. 2A, B). Here, SORL1 is linked to primary progressive aphasia.