TNFRSF10B and head and neck squamous cell carcinoma: In addition, we observed that HPV(+) HNSCC cells exhibited genomic gain and/or overexpression of TRAIL and TRAILRs, and the stimulation of the death pathway through anti-TRAILR2/DR5 antibody agonist was very effective in inducing cell death in combination with birinapant and/or TRAIL.