FADD and head and neck squamous cell carcinoma: This could be explained by the oncogenic function of FADD30, or blocking of FADD-induced apoptosis through amplification and overexpression of the anti-apoptosis molecules BIRCs/IAPs, which have been observed in HPV(−) HNSCC and SCCs from other anatomical sites, including the lung, esophagus, cervix and bladder11.