To address these questions, we characterized the genomic and expression profiles of nine molecules involved in the extrinsic and intrinsic death pathways, including TRAIL (TNFSF10) and its receptors, FADD, BIRC2/3, and XIAP in HNSCC tissues differing in HPV status from TCGA datasets. The gene discussed is FADD; the disease is head and neck squamous cell carcinoma.