In addition, we observed a M1 Mφ profile induced by 4Mu in peri-tumor and non-tumor sections on day 15; Fig. 1b also showed the reduced percentage of F4/80+CD206+ cells (44.0 ± 0.63% vs. 72.0 ± 4.41%; ***p < 0.001 and 60.0 ± 1.90% vs. 78.2 ± 1.43%, *p < 0.05 4Mu vs. saline, respectively. Here, MRC1 is linked to neoplasm.