TNF and neoplasm: Although the levels of cytokines modulated in tumor hepatic Mφ on day 9 did not show clearly a definitive profile, there was a significant increase in the mRNA levels of IL1-B and TNF-α together with a decrease of TGF-β and IL-10 on day 15, which means a clear polarization induced in tumor hepatic M towards an M1 profile after 4Mu treatment (Fig. 1c).