Although a recent report identified that chronic iron exposure in human pancreatic ductal epithelial cell line supported epithelial-mesenchymal transition (EMT) and tumorigenesis through a p53-dependent mechanism105, the role of chronic iron overload in ovarian cancer initiation by mediating transformation of fallopian tube secretory epithelial precursor cells (FTSECs) remains unclear106. This evidence concerns the gene TP53 and ovarian cancer.