TP53 and ovarian carcinoma: Although a recent report identified that chronic iron exposure in human pancreatic ductal epithelial cell line supported epithelial-mesenchymal transition (EMT) and tumorigenesis through a p53-dependent mechanism105, the role of chronic iron overload in ovarian cancer initiation by mediating transformation of fallopian tube secretory epithelial precursor cells (FTSECs) remains unclear106.