Flow cytometry of primary ALL cells treated with NVP-BEP800 showed a reduction in tyrosine phosphorylation of LCK (p-LCK) in T-ALL cells (P < 0.0001) and tyrosine phosphorylation of LYN (p-LYN) in B-ALL cells (P < 0.001) (Fig. 3c). The gene discussed is LCK; the disease is acute lymphoblastic leukemia.